Purpose/goal of the project
The goal of this study is to assess the relationship between the nasal, skin, and gut microbiomes and MDRO colonization in children attending daycare in Wisconsin. Children in daycare settings are at an increased risk of carrying multidrug resistant organisms (MDROs) and the microbiome is thought to play an important role in mediating MDRO carriage.
Description of the study/SHOW involvement in the project
This is a cross-sectional study that will use the SHOW infrastructure to recruit and enroll children of daycare age from both existing SHOW participants and new SHOW families across Wisconsin. This study plans to enroll 80 children between the ages of 6 months and 5 years of age and will collect samples from the nose, skin, and stool of all participants.
Why the study is being done
Developing a microbiome that inhibits the growth of MDROs early in life is essential to preventing transmission of and infection with MDROs in this high risk setting. However, the lack of research in this area leaves many remaining questions and a gap in the field regarding the microbiome characteristics that are associated with MDRO carriage, at multiple body sites such as the nose, gastrointestinal tract and the skin which this study aims to begin to fill. The overarching goal of this research is to identify and test interventions to reduce MDRO infections in children by improving our understanding of the structure and function of the microbiome at nasal, gut, and skin sites.
Nasia Safdar, MD, PhD
Department of Medicine